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Sunday heralds the initial Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or Newcastle?
"During the bulk of last season, it was unthinkable Sunderland getting promoted and challenging with Eddie Howe's Newcastle, let alone being above them in the table," commented football expert Chris Sutton.
"The situation is very different now, and the way they play leads me to believe they've got a solid shot."
The analyst is providing predictions for all 380 Premier League games this campaign, against artificial intelligence, fans and a variety of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the England's esports team – the Football Association's official esports team – at the EA Sports FC Uefa eEuro 2025 finals tournament, which will occur at Twickenham Stadium on Saturday.
The action will be streamed on Uefa's YouTube, IG Live and TikTok channels, as well as the official Twitch channel and YouTube and England's Twitch.
What are your thoughts with their predictions? Feel free to submit your own predictions below.
The most commonly selected scoreline picked for each game is used in the leaderboards at the bottom of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth 10 points. A perfect prediction earns forty points.
Ray, who represents Gen City and Manchester City as well as England, is entering the fray at the eEuros finals after successfully navigating the preliminary stage.
Eight players will fly the flag at the finals in a straight knockout, playing for a six-figure prize fund and a coveted spot in the FC Pro World Championship Play-Ins, with the Danish representative Anders Vejrgang looking to retain the title he won last year.
"My mindset is really good for it," Ray said. "There's a really good coach alongside me and practice has been going well.
"It is invariably an honour to play for your country. Obviously when you are younger, you dream about doing it as an real-life footballer, but when you enter this job and there is an opportunity to represent England, donning the national jersey is something incredible.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him recently just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"I believe he is the number one in the world so defeating him in a tournament like this just gives you a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were impressive against the Gunners at the end of November, when they got a draw after being reduced to 10 men, and I was thinking here we go, they could possibly be title contenders.
However, since that game, however, they were beaten physically by Leeds, looked uninspired against Bournemouth and this week got turned over by Atalanta in the Champions League.
So boss Enzo Maresca really needs a win here to restore momentum, but it won't be easy because Everton are such a threatening team.
Two of their stars are playing really well and they have got a bit of form at the moment.
Current evidence suggests you would probably back Everton, while the most logical prediction would probably be a draw, but I'm going against logic.
The Blues have failed to given me any compelling evidence to back them recently, but I just have a feeling Chelsea will emerge victorious because they are at home and they are in need of three points.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be fascinating to see what we get from the Reds.
I was delighted for Reds boss Arne Slot to get such a great win at Inter Milan on Tuesday following all the discussion with Mohamed Salah this week.
Slot shouldn't need to put up with that nonsense. I know Salah has been a icon for the club but fundamentally Slot just wants to win games and there is no ulterior motive in his team selection.
They changed their tactical setup against Inter and went with a midfield diamond and two up top.
All the talk is going to be talking about whether Salah is included for this game, but the only way he is going to be reintegrated is if he says sorry.
Slot's primary concern will be on winning this game, but it is a challenging encounter.
It's fair to say it is the same for most teams but I find Brighton so unpredictable. I always feel they have got a goal in them, but they are defensively susceptible too.
The Merseysiders need to get back to winning consistently, but I am not sure how much their energy spent at the San Siro will have drained them.
I put a couple of Brighton players in my Fantasy Premier League side, so they will probably lose now - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the opportunity to rest while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
Apart from their superb performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, particularly straight after they've played in the Champions League.
The pattern suggests that pattern to continue on Sunday, and their fatigue is likely to be a key element in how this game goes because of Sunderland's intensity.
It was evident how relentless Regis le Bris's side are. They dominated the Gunners, and it was amazing to watch.
Everyone talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays alongside him, has also been one of the signings of the season and should be recognised too.
I am expecting this being the best game|most exciting fixture